A pharmaceutical, in the dosage form, contains the active pharmaceutical ingredient (API), which is the drug itself, and excipients, which are the substances of the tablet (or pill), or the liquid the API is suspended in, or other material that is pharmaceutically inert. The active ingredients are the reason why the drugs are primarily chosen. The Active Pharmaceutical Ingredient (API) is the part of any drug that produces its effects. Some drugs, such as combination therapies, have multiple active ingredients to treat different symptoms or act in different ways.

All drugs are made up of two core components: the API, which is the central ingredient, and the excipients, the substances other than the drug that helps deliver medication to the body. Excipients are chemically inactive substances, such as lactose or mineral oil. For instance, if you have a headache, acetaminophen is the active ingredient, while the liquid in the gel-capsule or the bulk of a pill is the excipient.

Manufacturers use certain standards to determine how strong the API is in each drug. However, the standard can vary widely from one brand to another. One brand might use one test, another a different one. In all cases, manufacturers are required by the FDA to prove the potency of their products in real life patients, as well as laboratory conditions. The quality of APIs has a significant effect on the efficacy and safety of medications. Poorly manufactured or compromised APIs have been connected to serious issues, such as illnesses and even death.

Production of APIs has traditionally been done by the pharmaceutical companies themselves. But in recent years many corporations depend on API manufacturing overseas due to significantly lower costs. This has necessitated changes to how these drugs are regulated, with more rigorous guidelines and inspections put into place. Even in the case of outsourcing, APIs are subject to stringent regulations and oversight from the country they are shipped. For example, API manufacturing plants overseas will still go through an inspection by the U.S. Food & Drug Administration and obtain regular certification and re-certification before they become eligible to ship their APIs.

TNN has partnered with leading overseas API and excipient manufacturers to supply high-purity and thoroughly tested APIs/excipients. TNN oversees the development of the relationship between the manufacturers and the end users and then be responsible for the quality certification, logistics and timely delivery of the materials. A few of the APIs and excipients handled by TNN are shown in the tables below.

Pharmaceutical Raw Materials (API) Specification Application / Purpose
PenicillinsFor Infections and Infestations
CephalosporinsFor Infections and Infestations
Chloramphenicol Levo BP/EP/USPFor Infections and Infestations
Chlortetracycine EPFor Infections and Infestations
Doxycycline HClBP/EP For Infections and Infestations
OxytetracyclineBPFor Infections and Infestations
Tetracycline HClBP/USPFor Infections and Infestations
Azithromycin USPFor Infections and Infestations
ClarithromycinUSPFor Infections and Infestations
Clindamycin HCl/PhosphateUSPFor Infections and Infestations
ErythromycinUSPFor Infections and Infestations
Licomycin HClEPFor Infections and Infestations
Spiramycin USPFor Infections and Infestations
Amikacin Sulphate USPFor Infections and Infestations
Gentamycin Sulphate USPFor Infections and Infestations
Neomycin SulphateEP/USPFor Infections and Infestations
Streptomycin SulphateEPFor Infections and Infestations
Tobramycin Base/SulphateUSPFor Infections and Infestations
Ciprofloxacin USPFor Infections and Infestations
Norfloxacin USPFor Infections and Infestations
LevofloxacinUSP/In-houseFor Infections and Infestations
Ofloxacin USPFor Infections and Infestations
FosfomycinEPFor Infections and Infestations
Spectinomycin HCLUSPFor Infections and Infestations
SulfadiazineBP/USPFor Infections and Infestations
SulfamethoxazoleBP/USPFor Infections and Infestations
SulfanilamideBPC/EPFor Infections and Infestations
TrimethoprimUSPFor Infections and Infestations
Clotrimazole USPFor Infections and Infestations
IsoniazidBP/EPFor Infections and Infestations
FurazolidoneBPFor Infections and Infestations
NitrofurantoinBPFor Infections and Infestations
Terbinafine HClEPFor Infections and Infestations
Levamisole HClBP/EPFor Infections and Infestations
Metronidazole (Benzoate)BP/USPFor Infections and Infestations
PraziquantelUSPFor Infections and Infestations
Pyrimethamine BPFor Infections and Infestations
SulfadoxineBPFor Infections and Infestations
Analgin (Metamizole Sodium)DAB/EPFor Pain Relief, Fever and Consciousness
Antipyrine USPFor Pain Relief, Fever and Consciousness
AspirinBP/USPFor Pain Relief, Fever and Consciousness
Chlorzoxazone USPFor Pain Relief, Fever and Consciousness
Diclofenac Sodium BP/USPFor Pain Relief, Fever and Consciousness
HydrochlorothiazideUSPFor Pain Relief, Fever and Consciousness
IbuprofenUSPFor Pain Relief, Fever and Consciousness
KetoprofenUSPFor Pain Relief, Fever and Consciousness
Mefenamic AcidBP/EP/USPFor Pain Relief, Fever and Consciousness
ParacetamolBP/EP/USPFor Pain Relief, Fever and Consciousness
PhenacetinBP For Pain Relief, Fever and Consciousness
Candesartan CilexetilEP/USPFor the Cardiovascular and Blood System
Captopril EP/USPFor the Cardiovascular and Blood System
DiosminEPFor the Cardiovascular and Blood System
Enalapril MaleateEP/USPFor the Cardiovascular and Blood System
Fructose Diphosphate SodiumFor the Cardiovascular and Blood System
IrbesartanEP/USPFor the Cardiovascular and Blood System
LisinoprilEP/USPFor the Cardiovascular and Blood System
Losartan PotassiumEP/USPFor the Cardiovascular and Blood System
RutinEPFor the Cardiovascular and Blood System
Methyl DopaBP/USPFor the Cardiovascular and Blood System
SimvastatinEP/USPFor the Cardiovascular and Blood System
Tranexamic AcidBPFor the Cardiovascular and Blood System
ValsartanEP/USPFor the Cardiovascular and Blood System
Aminophylline AnhydrousBP/USPFor the Respiratory System
Bromhexine HClBPFor the Respiratory System
CarbocisteineEPFor the Respiratory System
Codeine PhosphateBP/USPFor the Respiratory System
GuaifenesinEP/USPFor the Respiratory System
Noscapine HClBP/USPFor the Respiratory System
RacecadotrilEPFor the Respiratory System
Caffein AnhydrousBP/EP/USPFor the Central Nervous System
CarbamazepineBP/USPFor the Central Nervous System
Citicoline SodiumCPFor the Central Nervous System
Lidocaine Base/HClBPFor the Central Nervous System
Amino AcidsFor Nutrition
MineralsFor Nutrition
VitaminsFor Nutrition
Activated CarbonOther Use
Aluminium HydroxideUSPOther Use
BenzocaineUSPOther Use
Beta-EcdysoneOther Use
BoraxBPOther Use
Boric Acid BPOther Use
Dextrose BP/USPOther Use
Diphenhydramine HCLBP/USPOther Use
FurosemideBPOther Use
Magnesium Sulfate BP/USPOther Use
Mannitol BP/USPOther Use
Menthol BP/USPOther Use
Methyl Salicylate BP/USPOther Use
Ox Bile 40%/45%Other Use
Potassium ChlorideBPOther Use
PrednisoloneUSPOther Use
Salycilic AcidBP/USPOther Use
Sodium Bicarbonate BPOther Use
Sodium ChlorideBPOther Use
Sorbitol Other Use
Corn Starch
Hydroxy Propyl Methyl CelluloseUSP
Lactose Anhydrous/MonohydrateBP/USP
Lanolin AnhydrousEP/USP
Magnesium StearateBP/USP
Methyl/Propyl Paraben (Sodium)BP/USP
Microcrystalline CelluloseUSP
Poloxamer EP/USP
Propylene Glycol0.995
Polyethylene Glycol400-6000
Polyoxyl 40 StearateCP/USP
PVP (Polyvinyl Pyrrolidone)EP/USP
Sodium SaccharinBP/USP
Sodium Starch GlycolateUSP
Stearic AcidUSP